Politically Animated studies the convergence of animation and actuality within films, television series, and digital shorts from across the Spanish-speaking world. It interrogates the many ways in which animation as a stylistic tool and storytelling device participates in political projects underpinning an array of non-fiction works.

The case studies in the book cover a diverse geographical scope, including Spain, Argentina, Colombia, and Mexico. They critically analyse different works such as feature-length animated documentary films, a work of animated journalism, a short animated essay, and micro-short episodes from a televised animated documentary series. Jennifer Nagtegaal employs the term "politically animated" in reference to the ideological implications of choosing specific techniques and styles of animation within certain socio-historical and cultural contexts.

Nagtegaal illuminates the creative union of animated documentary and the comics medium currently being exploited by Spanish and Latin American cartoonists and filmmakers alike. By paying particular attention to cultural production beyond the big screen, Politically Animated continues to stretch the bounds of animated documentary scholarship.