In an alchemical ritual gone wrong, Edward Elric lost his arm and his leg, and his brother Alphonse became nothing but a soul in a suit of armor. Equipped with mechanical "auto-mail" limbs, Edward becomes a state alchemist, seeking the one thing that can restore his and his brother's bodies...the legendary Philosopher's Stone.

Accompanied by their bodyguard, Alex Louis Armstrong, our heroes seek out their closest childhood friend, Winry Rockbell, to fix their battered "auto-mail" bodyparts. Soon their quest for the Philosopher's Stone takes them to the great central library, where the Stone's formula may be hidden...if the mysterious figure named Lust doesn't get there first! But the secret of the Philosopher's Stone may be even more frightening than the beings who guard it...