One fateful day, all of humanity turned to stone. Many millennia later, Taiju frees himself from the petrification and finds himself surrounded by statues. The situation looks grim--until he runs into his science-loving friend Senku! Together they plan to restart civilization with the power of science!

Upon arriving at a primitive village, science fanatic Senku schemes to recruit the villagers to help him bring about a new civilization based on science! His first target is a young, inquisitive villager named Chrome, whom Senku wins over by defeating him in a battle of wits. Their first big task? To find a cure for Kohaku's older sister and the village shamaness--Ruri!