At Hemlock Heart Academy, science wiz Kazu Decker shows off his skills by creating a humanoid girl named Pandora. But in a world of monsters and mayhem, surviving high school is harder than getting good grades, and lessons often turn violent. Fortunately for them, Pandora's stoic nature and seemingly limitless strength, paired with Kazu's luck, knowledge and friends, get them out of trouble almost as often as they get mixed up in it!

Science projects at Hemlock require more than a fizzy volcano to impress the class, so naturally Kazu introduces them to Pandora, whose violent streak and impressive strength cause more destruction in his already chaotic school life. Braving runaway science experiments, howling apparitions and a deadly fashion show, Pandora learns that life at a devil high school is a day-to-day struggle for survival.