In a world where monsters called Yoma prey on humans and live among them in disguise, humanity's only hope is a new breed of warrior known as Claymores. Half human, half monster, these silver-eyed slayers possess supernatural strength but are condemned to fight their savage impulses or lose their humanity completely.

Clare and her fellow Claymores are nearing the end of their strength in their battle against the Awakened Being--a male ex-Claymore who can no longer control his Yoma powers. Not only is Clare the weakest among them, but she has taken the brunt of the creature's attacks as well, and yet she may be their only hope in discovering the Awakened Being's weakness.